CHOLESTEROL :
Familial Hypercholesterolemia, an inherited disorder that causes severely elevated cholesterol levels.
Cholesterol is a building block for vitamin D and hormones in the body. However, high Low-Density Lipoprotein (LDL) cholesterol, or “bad cholesterol”, is a risk factor for developing heart disease, which can result in a heart attack or stroke.
Lipoprotein (a) is a form of Low Density Lipoprotein (LDL) in which another protein, called Apo(a), is attached to each LDL particle as it carries cholesterol around in the body. Having elevated blood levels of Lipoprotein (a) raises a person’s risk of heart attack and stroke beyond what is normally seen from elevated LDL cholesterol alone. This is believed to be due to the Apo(a) protein, which may reduce the body’s ability to break down clots.
Elevated Lipoprotein (a) is usually inherited from one parent. About 1 in 4 people in the population are believed to have elevated blood levels of Lipoprotein (a). African Americans may have higher levels. Besides genetics, Lipoprotein (a) levels may result from increased intake of some types of fats, and some medical conditions. Treatment of elevated Lipoprotein (a) is based on a person’s risk of heart attack or stroke. A healthy diet and lifestyle are the first step to reducing heart attack and stroke risk from elevated Lipoprotein (a). Medications also may help. ‘ Statins’ do not lower Lipoprotein (a) levels. However, statins are the most used medication for lowering heart attack and stroke risk in general, and so they are the most used medicine to treat risk from elevated Lipoprotein (a). Niacin can lower Lipoprotein (a) levels by 25-40%, as can PCSK9 inhibitors, but both are used less often. A new medication for lowering Lipoprotein (a) is being tested.

Lipoprotein (a) testing is usually recommended for people who have a personal or family history of early heart attack or stroke.
Lipoprotein (a) testing may also be recommended in people who have early aortic valve narrowing or ‘stenosis’

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